SAVING LIVES WITH AI
The new “Claude Science” from Anthropic uses artificial intelligence to tackle rare genetic disorders and tropical maladies, the kind that are usually ignored because there aren’t enough patients to justify the costs involved in finding a cure.
It sounds almost miraculous but it can’t do human testing. So the company is hoping it will be a helpful tool for anyone from giant pharmaceutical companies down to individual researchers.The beta version is available to paid Claude users (currently macOS/Linux) starting at $20 a month.
However, the field is ripe with competitors. Insilico Medicine, Recursion, Exscientia and Isomorphic Labs are all involved in AI drug discovery. In July 2026, Insilico launched a Phase III trial for “Rentosertib,” an oral medication for idiopathic pulmonary fibrosis, a progressive and currently incurable lung-scarring disease.
Most notably, AI designed the biological target that Rentosertib attacks and identified its chemical structure. It’s the first AI-generated drug to reach Phase III, the second-to-last stage of human testing. Phase IV is conducted only after the drug is approved and marketed.
In 2023, the FDA granted it Orphan Drug status, which gives the company exclusive seller rights for seven years. A more recent trial showed that patients on Rentosertib had improved lung function compared to those on a placebo. If Rentosertib’s latest trial succeeds, it could prove that AI-designed medicines can make it all the way through the approval pipeline.
Going Back to Windows 10
Ever since a reader named John bought a Windows 11 laptop from Lenovo, he’s had “a plethora of frustrating problems.” Now, he’s thinking of turning it into a Windows 10 machine. Good idea.
The problems began when Microsoft changed many gesture features for Windows 11. The difficulties are especially noticeable in two-in-one laptops like John has. In short, Windows 11 gets confused when a user tries to click, tap, drag or highlight a passage. He says it often takes him three tries to get a response.
But the problem isn’t unique to his Lenovo 2-in-1. It also applies to Dell Inspiron and XPS laptops, HP Envy and Specter 2-in-1s, Asus ZenBooks and more. So by going back to Windows 10, John’s laptop should respond normally. (Get Windows 10 for free at Microsoft.com.)
Can you install Windows 10 over 11? Nope. During a Windows 10 installation, you must allow the process to completely wipe your laptop’s primary drive. But don’t worry. If you back up your files first, you can easily restore them, though your programs and apps must be manually reinstalled. A note of caution: Go to your laptop’s support site first. Some machines are built strictly for Windows 11.
High Tech Shoes
Need a little pep in your step? A new kind of shoe has a robotic insert to help lighten your load.
The Dephy Sidekick is a $4,500 way to ease joint problems. Its special shoes lock into motorized devices that attach to your lower legs with straps. It feels like wearing boots, according to a ZDnet reviewer. To me, it looks like a metallic version of the shin guards I wore in high school for field hockey.
The Dephy’s AI system calibrates your gait to provide a customized lift, and has three power levels. Though designed for the Army, the company claims it can save your knees and hips from the ravages of old age. Check it out at dephy.com.
Bye Bye Physical Discs
A hip college student told me she’s a big fan of PlayStation games but hates the online versions. Unfortunately for her, Sony is phasing out physical discs. As of 2028, she’ll only be able to buy new games online, though she’ll be able to buy any game in disc form that was produced before 2028.
According to Engadget, this is part of a trend. Many games now have a code in a box instead of a disc, and Nintendo is charging more for physical editions of some of its games.
Avoiding Amazon Phonies
“Knockoff,” which is free at the website Knockoff.shopping, is a new extension that tries to pinpoint brands on Amazon that may be fake. It can’t really detect the phonies, however. It just flags the products with gibberish, all-caps, vowel-less names typical of anonymous mass-market dropshippers.
After reading about it in CNET, I searched for “solar lights” on Amazon. About half the choices were grayed out. But sometimes Knockoff makes a mistake. According to CNET, it blocked Torras, a well-known phone case brand, which is in stock at Best Buy.
Portable Shower
If a storm knocks out the power grid, having a portable shower system that heats water to 140 degrees Fahrenheit might save the day. It could also be useful for washing the kids and the dog, especially if they like to take off after that first bucket of water pours on their heads.
The HotTap Go is a $554 portable shower from joolca.com. Your car’s 12-volt socket, what we used to call a cigarette lighter, powers the water pump. The heat, up to 140 degrees Fahrenheit, comes from a small propane/gas burner built into the unit. If you wish, you can stick the showerhead on the side of your car, since it’s magnetized. This way you get a powerful spray any place you happen to be, whether at a camping site, on your boat or in your own backyard.
Filed under: AI, gadgets, health, numbers, trends, Windows | Add New Comment »
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